Sertraline alone does not seem to have any impact on blood pressure.
Sertraline, which is sometimes distributed under the brand name Zoloft®, is in a class of drugs called selective serotonin reuptake inhibitors (SSRIs), used to treat depression. Clinical studies do not indicate a connection between normal sertraline use and blood pressure changes in adults, although a combination of sertraline with L-tryptophan is known to cause a condition that can affect blood pressure. Furthermore, a possible correlation was found between taking SSRIs during pregnancy and the occurrence of persistent pulmonary hypertension in the newborn (PPHN). Sertraline is prescribed for major depressive disorder and other types of mental disorders.
Sertraline works by helping to balance the level of serotonin in the brain.
Studies of sertraline and its effects with normal use in patients have not shown any correlation between sertraline and blood pressure. In clinical studies, the percentage of people who took sertraline who reported a change in blood pressure was nearly equal to the percentage of those in a control group who took a placebo or sugar pill without medication. When taken in combination with L-tryptophan, which is used to treat bipolar affective disorder, there is a connection between sertraline and blood pressure. This drug combination is known to cause a serious condition called serotonin syndrome. Symptoms of this condition include changes in blood pressure, as well as restlessness, increased heart rate, and hallucinations.
A 2006 study in the New England Journal of Medicine of SSRIs and their impact on pregnant women and their babies found a higher incidence of PPHN. According to this study, the timing of exposure to SSRIs was critical. For mothers who took SSRIs after the 20th week of pregnancy, the incidence of PPHN was more than double that of the control group.
PPHN is a fatal disease in newborn babies that causes blood to leak out of the lungs. The newborn can die because the blood is not oxygenated. Previous studies on the effects of SSRIs on pregnant women have found no correlation between this fatal disease and the use of SSRIs during pregnancy. Some experts say the risks of PPHN should be compared to the effects of depression on mothers and newborns.
Sertraline is prescribed for depression and works by helping to balance the level of serotonin in the brain. This medication is also prescribed for a number of other mental health conditions, including major depressive disorder, obsessive-compulsive disorder, panic disorder, and post-traumatic stress disorder. It is also sometimes used to treat chronic pain and Alzheimer’s disease. While there isn’t much evidence of a correlation between sertraline and blood pressure changes, the drug has other common side effects that include dry mouth, difficulty sleeping, dizziness, and headache.