What differentiates granular tissue from granulomatous tissue?

Granular tissue is a type of fibrous connective tissue that forms during wound healing. This tissue forms along fibrin clots and grows until the clots are replaced by new tissue.

The granular tissue starts as light red or dark pink and perfuses to cover the entire surface of the wound, regardless of size.

Its appearance is moist, light red or dark pink, and with an irregular surface, which it owes the name of granular tissue.

It consists of an extracellular matrix that houses various types of cells that make the matrix itself grow and a new vascular network to supply the new growing tissue. Immune system cells, including macrophages and neutrophils, also migrate into the granular tissue.

Granulomatous tissue, on the other hand, is a tissue that presents granulomas, something completely different from granular tissue, but which is often confused by the similarity of its name.

granulomas These are formations of the inflammatory type produced by the immune system to isolate a substance or foreign body that it has not been able to eliminate.

Granulomas are only visible under a microscope, while granular tissue can be identified with the naked eye.

Granular tissue appeared in wounds as a healing mechanism. Granulomas and granulomatous tissue appear in many types of diseases, especially infectious diseases and chronic inflammatory diseases.


Granuloma seen under a microscope Granular tissue in a finger wound

Leave a Comment